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How Long Do Different Drugs Stay in Your System?

Home / Drug Testing / How Long Do Different Drugs Stay in Your System?

November 27, 2017 by David Bell

Last updated: January 30, 2023

Different types of drugs stay in the body for different lengths of time after last use, depending on several factors, and the detection window for identifying drug use varies, depending on these factors and the drug testing method, such as urinalysis, oral fluid, or hair, that is used to collect a specimen.

Certain drugs, like marijuana, will remain in a users system significantly longer if they are used more frequently, because they are stored in the body, rather than being quickly excreted as they would in an occasional user. Other drugs, like cocaine, tend not to build up in a users body regardless of how frequently they are used. Most drugs will remain identifiable in a urine sample for significantly longer than they will in saliva sample, while a hair sample will provide the longest detection window, regardless of the drug in question.

Some of the factors that may affect how long drugs stay in someone’s system include:

  • Type of drug
  • Dosage
  • Frequency of use
  • Health
  • Metabolism
  • Weight, height, and gender

Drug testing methods

Urinalysis drug test

Urinalysis is the industry standard, and currently, the only method approved for DOT drug testing. This method is fast, easy, and inexpensive, but it does have some drawbacks. You need to secure a private restroom, disable the sink and toilet, and place a bluing agent into the water in the toilet bowl. Privacy concerns may also be an issue because a test must be conducted by an administrator of the same sex.

This method has a long detection window but cannot detect drug use that has occurred within the last few hours.

Oral fluid / mouth swab drug test

Mouth swab drug testing is just as accurate as urinalysis. It’s also just as fast, easy, and inexpensive, but by far, its greatest advantage is that it can be conducted literally anywhere—even in plain view of other employees, because it only requires a sterile cotton swab to be rubbed along the inner cheek to collect a small saliva sample.

While this method has the shortest detection window, it can detect drug use almost immediately after use.

Hair drug testing

Hair drug testing offers the same convenience of oral fluid drug testing, and can be conducted anywhere, but it is more expensive than other methods. This test requires the collection specialist to clip a small 1” wide section of hair, preferably near base of the scalp, and secure it in a specially labeled container. While this testing method is easy and convenient, some employees may take issue with having their hair cut.

This method has the longest detection window, but it cannot detect recent drug use.

Drug use detection windows

Amphetamine-Type Stimulants LOQ (ng/mL) Detection Time* up to
Amphetamine 25 3 days
Methamphetamine 25 3 days
3,4‑Methylenedioxyamphetamine (MDA) 25 2 days
3,4‑Methylenedioxymethamphetamine (MDMA) 25 2 days
Phentermine 25
Ephedrine/pseudoephedrine 25 5 days

Note: These tests do not differentiate between dextro (+) amphetamines (eg, dexamphetamine) and racemic mixtures of dextro (+) and levo (-) isomers that are present in “street” amphetamines. These tests do not differentiate between ephedrine and pseudoephedrine.

Barbiturates LOQ (ng/mL) Detection Time* up to
Long-Acting
Phenobarbital 100 15 days
Intermediate-Acting
Butalbital 100 7 days
Amobarbital 100 3 days
Short-Acting
Pentobarbital 100 3 days
Secobarbital 100 3 days
Benzodiazepines LOQ (ng/mL) Detection Time* up to
Long-Acting 10 days
Diazepam as metabolites 100
Nordiazepam 100
Intermediate-Actingc
5 days
Alprazolam as metabolite 100
Lorazepam 100
Oxazepam >100
Temazepam 100
Chlordiazepoxide as metabolite 100
Clonazepam as metabolite 100
Flunitrazepam as metabolite 50
Short-Acting 2 days
Triazolam as metabolite 100
Flurazepam as metabolite 100
Buprenorphine LOQ (ng/mL) Detection Time* up to
Buprenorphine 0.5 7 days
Norbuprenorphine 0.5 7 days
Cocaine & Metabolite LOQ (ng/mL) Detection Time* up to
Cocaine 50 <1 day
Benzoylecgonine 50 5 days
Fentanyl LOQ (ng/mL) Detection Time* up to
Fentanyl 0.2 3 days
Norfentanyl 1.0 3 days
Ketamine LOQ (ng/mL) Detection Time* up to
Ketamine 25 2 days
Norketamine 25 2 days
Lysergic Acid Diethylamide (LSD) LOQ (ng/mL) Detection Time* up to
LSD 0.5 <1 day
2‑Oxo‑3‑hydroxy‑LSD 5 5 days
Marijuana/Cannabis (THC-COOH) LOQ (ng/mL) Detection Time* up to
Single Use 3 3 days
Moderate Use (4 times per week) 5 days
Heavy Use (daily) 10 days
Chronic Heavy Use 30 days
Methadone LOQ (ng/mL) Detection Time* up to
Methadone 100 7 days
EDDP (methadone metabolite) 100 7 days
Opiates LOQ (ng/mL) Detection Time* up to
6-MAM  5 <1 day
Codeine 25 3 days
Dihydrocodeine 25 3 days
Hydrocodone 25 3 days
Norhydrocodone 25 3 days
Hydromorphone 25 3 days
Oxycodone 25 3 days
Noroxycodone 25 3 days
Oxymorphone 25 3 days
Noroxymorphone 25 3 days
Naloxone 25 3 days
Morphine 25 3 days
Phencyclidine LOQ (ng/mL) Detection Time* up to
Phencyclidine 25 8 days

*These are approximate detection times for the drug or metabolites in urine. The actual detection time depends on dose, frequency of use, and individual metabolism.

Filed Under: Drug Testing

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About David Bell

After seeing the damage caused by drug use first-hand, David sold his previous company and worked his way up through the ranks in the drug testing industry to help employers keep drugs and alcohol out of the workplace.

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